Scleroderma is a chronic but uncommon autoimmune condition in which collagen-rich, thick tissue replaces healthy tissue. Scleroderma can affect many different body areas, yet it often only affects the skin.Scleroderma is an uncommon but chronic autoimmune condition in which dense, thick fibrous tissue replaces healthy tissue. The immune system often aids in the body's defense against illness and infection. Scleroderma sufferers' immune systems cause other cells to overproduce the protein collagen. This excess collagen is deposited in the organs and skin, causing thickening and hardness (a process akin to scarring). Scleroderma can affect the gastrointestinal system, lungs, kidneys, heart, blood vessels, muscles, joints, and skin, however it often just affects the skin. In its most extreme forms, scleroderma can be fatal. Localized and systemic scleroderma are the two main types. There are two basic forms of systemic scleroderma: diffuse and restricted. Localized scleroderma, which is the disease's most prevalent type, only affects a person's skin, often in a few locations. It frequently manifests as waxy streaks or spots on the skin, and this less severe type frequently stops developing or disappears without medical intervention.
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