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Formerly known as Wegener's disease, granulomatosis with polyangiitis is a rare ailment that can affect anyone of any age and has no known cause. It is referred to as vasculitis, which is an inflammation of several tissues, including blood vessels, but primarily of the kidneys and respiratory system. Granulomatosis with polyangiitis, sometimes known as Wegener's disease or GPA, is an uncommon condition with an unknown aetiology. It is the outcome of granulomatous inflammation and vasculitis, two types of inflammatory reactions to tissues that can harm organ systems. GPA can affect any place, however the lungs, kidneys, and sinuses are the most often impacted organs. Vasculitis is a general term that refers to inflammation of the blood vessels. When inflamed, the blood vessel may become weakened and stretch forming an aneurysm, or become so thin that it ruptures resulting in bleeding into the tissue. Vasculitis can also cause blood vessel narrowing to the point of closing off the vessel entirely. This can cause organs to become damaged from loss of oxygen and nutrients that were being supplied by the blood.
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